Not sure, but since I downloaded the HTC Inspire Update last week, I have not been able to sync with my PC, and get a "USB debugging error" message from Microsoft. I have spent the better part of 2 days with 3 different HTC techs to no avail. They say the only option is a factory reset, meaning I'll lose everything I've put on the phone since May. Ugh!
I doubt that would work anyway, b/c I downloaded the update onto my laptop, and it syncs fine.